Anatomo-pathological Multidisciplinary Study of the Sudden Unexpected Death

1226 E Avenida Kino,Casa Grande AZ 85122

05 January, 2023

Description

Sudden unexpected death (SUD) is a fatal event that occurs in an apparently healthy subject so that such an abrupt outcome could have not been predicted. SUD includes sudden intrauterine unexplained death (SIUD), sudden infant death syndrome (SIDS), and sudden unexpected death of the young (SUDY). Sudden infant death syndrome (SIDS), or crib death, is the sudden unexpected death of an infant less than one year of age, with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a thorough investigation, including performance of a complete autopsy and review of the circumstances of death and the clinical history. SIDS is the most frequent death-causing syndrome in the first year of life, at a death rate of 0.42 per 1,000 births. Sudden intrauterine unexplained/unexpected death (SIUD), or unexpected stillbirth, is the late fetal death before the complete expulsion or removal of the fetus from the mother ≥25 weeks of gestation which is unexpected by history and is unexplained after review of the maternal clinical history and the performance of a general autopsy of the fetus, including examination of the placental disk, umbilical cord and membranes, and microbiological and genetic investigations. SIUDS has a 6-8 fold greater incidence than that of the SIDS that has not declined in the last 20 years significantly despite modern advances in maternal-infant care. The broad spectrum of SUD may have common risk factors affecting individuals of all ages, starting from intrauterine existence, such as endocrine disrupting chemicals (EDCs), or obstructive sleep apnea syndrome (OSAS), among many other potential environmental or genetic risk factors. The body of literature on the anatomo-clinical substrates of SUD and the relationship with risk factors and triggers is fragmentary and scarce. The main objective of this conference is to launch a multidisciplinary approach to SUD in the fields of anatomic pathology, toxicology, genetics, dentistry, and otolaryngology, in order to determine the presence of possible common risk factors for SUD at different ages.